台灣留學生出席國際會議補助

2009年6月10日 星期三

Minimally Invasive Parylene Dual-Valved Flow Drainage Shunt for Glaucoma Implant

論文發表人:林峻暉(加州理工學院電機系博士班)

 

http://www.mems2009.org/

 

本篇論文發表了一個由聚對二甲基苯材料所製作,應用於治療青光眼的雙節流閥控制流體之植入式元件。藉由整合的雙節流閥結構,此元件能夠以物理性的方式來排出過多的眼內液體以此來調節眼壓至適當的15-20豪米汞柱。除了基本的功能性微流體元件外,加上為手術而特別增加的設計,例如一個聚對二甲基苯容納管與固定器,也同時整合在此一元件當中,因此可以成功達成最小侵入式,術後無須縫合的手術目標。聚對二甲基苯固定器擁有一個非常深的半圓形溝槽,這是運用乾式薄膜光阻的技術製作而成。由於固定器的存在,可以防止元件在植入眼睛後發生滑動的現象。實驗室的實驗已經成功驗證了此一元件的確可以提供帶通式的流體控制結果,此結果完全可以滿足青光眼醫療上的需求。實驗結果也顯示,後製製程與封裝程序可以將節流閥完整封裝於聚對二甲基苯容納管內而在測試時並無液體滲漏的現象發生。所以此一元件已經適合用於活體實驗的階段。藉由最佳化後的微機電製程與後製製程,此一元件乃是第一個應用於醫療系統當中,可應用於治療青光眼,被動的,零電力消耗,也無須加入任何電路設計的雙節流閥式控制流體植入式元件。

 

A parylene-enabled microvalved shunt implant for glaucoma drainage is presented in this paper.  Enabled by the dual-checkvalve operation, this device can physically drain the extra intraocular fluid and regulate the intraocular pressure (IOP) within the normal range (15-20 mmHg).  Improved surgical features, in addition to the functional/microfluidic components, such as parylene-tube carrier and anchors, are also incorporated in such device to realize minimally invasive suture-less implantation, suitable for practical in vivo use. The parylene anchor with very deep semi sphere recess is fabricated utilizing the dry film photolithography technique.  With this improved surgical features and the newly developed packaging techniques, the overall finished GDD form factor not only still keeps minimally invasive implantation possible, but also prevents dislodging after subconjuctival implantation.  A pressure-bandpass configuration is characterized by on bench verification which illustrates that the results meet medical requirements to treat glaucoma patients.  It also shows that the epoxy and photoresist sealing during the packaging and testing procedures secure the system from water leakage extremely well.  With the optimized micromachining and post-fabrication process procedures, the developed implant is the first checkvalved glaucoma drainage device (GDD), which is passive, consumes no additional power, and functions without any circuit involved to pursue its medical application.